Latest comments

In response to: A New Addiction Science Network Resource -- Welcome to the "Blog!"

the professor [Member]
We have been forced to move to a "moderated" structure because of the heavy spam left in open, user-initiated, unmoderated posts (for an example of the potential for abuse, see the server overload we experienced when the 'gate' was left open as described in our posting "Unscheduled Service Disruption to all ASNet Resources.") We will continue to permit the free, open exchange of ideas and positions on topics related to drug addiction, substance abuse, and psychopharmacology, but we now must impose a slight delay while new posts are reviewed to insure that they are legitimate posts and not spam. We still do not technically moderate the posts; we will gladly present opposing views including those which conflict with our own opinions and position statements. The "moderation" is strictly to ensure legitimate posts and prohibit spam or commercial promotions for other websites and treatment centers. Sorry for any inconvenience and please continue to leave your comments and feedback.
PermalinkPermalink 09/12/12 @ 16:22

In response to: Proposed Regulation of Salvia Divinorum

john panos [Member]
Hello Professor,

I will be commenting more on Salv A and kappa agonists in the near future. However, I would like to propose a new topic on the scheduling of MDMA and whether there exists a therapeutic use for the drug.

John
PermalinkPermalink 10/20/11 @ 17:44

In response to: Proposed Regulation of Salvia Divinorum

john panos [Member]
Hello Professor,

Controlled human psychopharmacology studies have now been conducted and published on Salv A.

John

Matthew W. Johnson, Katherine A. MacLean, Chad J. Reissig, Thomas E. Prisinzano, Roland R. Griffiths, Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum, Drug and Alcohol Dependence, In Press, Corrected Proof, Available online 4 December 2010, ISSN 0376-8716, DOI: 10.1016/j.drugalcdep.2010.11.005.
PermalinkPermalink 01/03/11 @ 19:10

In response to: Proposed Regulation of Salvia Divinorum

john panos [Member]
Hello Professor,

Below is a reference to an article by Seeman et al. (2009). This may possibly add a little controversy to the discussion and lend support to Braida's work.

Seeman, P., Gaung, H.C., and Hirbec, H. (2009). Dopamine D2High Receptors Stimulated
by Phencyclidines, Lysergic Acid
Diethylamide, Salvinorin A, and Modafinil
Synapse 63:698-704

John

PermalinkPermalink 08/13/10 @ 12:18

In response to: Why Distinguishing between Drug Abuse and Drug Addiction is Important

While I personally do equate drug abuse and drug addiction to the same thing, I do think that the difference between the two is important as well.

For me, I say the two are natuarlly linked because drug addiction is a disorder where it is a dominant influence, and if that's the case, you could consider that as a form of abuse sinec that is taking priority over anything else, at least, that's what I think.
PermalinkPermalink 06/13/10 @ 15:02

In response to: Recreational Drug Use: Do People Living in a Free Sociey have the Right to use Psychotropic Substances "Recreationally"?

Hmm......I think as long as the substance in question isn't one that is instantly addicting and have drastic harmful affects, it should be fine that someone should take them, as long as they regulate it. Particularly, when it comes to marijuana, I think if it is treated like alcohol, you'll be fine.
PermalinkPermalink 06/13/10 @ 15:01

In response to: Dr. Phil's "Addiction"

kelly [Visitor] · http://www.drugrehabranch.com
Keeping it real - Dr. Phil
PermalinkPermalink 05/23/10 @ 19:11

In response to: Proposed Regulation of Salvia Divinorum

john panos [Member]


Psychopharmacology- Special Issue on Kappa-Opioids

http://www.springerlink.com/content/g2p32201l135/?sortorder=asc

PermalinkPermalink 05/09/10 @ 18:16

In response to: Position Statement on Medical Marijuana

PAMELA D WEAVER [Visitor]
WE NEED YOU DR PHIL
PermalinkPermalink 05/08/10 @ 23:12

In response to: Dr. Phil's "Addiction"

PAMELA D WEAVER [Visitor]
WE NEED YOU DR. PHIL
PermalinkPermalink 05/08/10 @ 22:30

In response to: ASNet Updates via RSS/Atom Feeds

Corey Phillips B.A. CSAC [Visitor]
Please send the latest info on addiction and relapse prevention
PermalinkPermalink 05/07/10 @ 19:09

In response to: Drug Addiction as a "Disease"

Alex [Visitor] · http://unipapers.org/
I’ve never paid much attention to the differentiation between illness, disorder and disease… It was really interesting to read these comments and opinions. Still, whether it is a disease or not, I consider the drug addiction to be awful. I’ll use the post for my custom writing service.
PermalinkPermalink 04/28/10 @ 02:42

In response to: Proposed Regulation of Salvia Divinorum

john panos [Member]
Hello Professor,

Psychopharmacology will be releasing a special issue on kappa receptors. The issue will include 18 new articles please see the reference below for more information. This may shed some interesting light on the topic or raise more questions of interest.

John

Ascent of the kappa-opioid receptor in psychopharmacology
William A. Carlezon Jr. & Klaus A. Miczek
Psychopharmacology (2010)
DOI 10.1007/s00213-010-1849-0
PermalinkPermalink 04/22/10 @ 18:27

In response to: Recreational Drug Use: Do People Living in a Free Sociey have the Right to use Psychotropic Substances "Recreationally"?

Jerry [Visitor] · http://www.93x.com
Seems like a good way for governments to raise money (regulation and taxes).
PermalinkPermalink 04/17/10 @ 04:47

In response to: Drug Addiction as a "Disease"

Addiction compliance software [Visitor] · http://www.mycomplianceoffice.com
I think calling addiction a disease is a cop-out.
PermalinkPermalink 04/01/10 @ 13:27

In response to: Drug Addiction as a "Disease"

john panos [Member]
Hello Professor,

This may not be the proper category to address my question. What is your opinion on the hypothesis that drug addiction is a form of self-medication. Within this view the addicted individual may have chosen their particular drug to reach a state of positive affect to avoid a negative affect state. The individual may have originally been seeking a homeostatic balance for positive affect, but in turn after time the drug has changed the homeostatic set point thusly the individual now seeks the drug to maintain a homeostatic balance.

John
PermalinkPermalink 03/10/10 @ 11:09

In response to: Proposed Regulation of Salvia Divinorum

john panos [Member]
Hello Professor,
An additional reference of interest is Vortherms and Roth (2006). The author’s state; “Ultimately, clinical trials will be needed to resolve the potential role for selective KOR agents in treating mood disorders” (p.263). Further preclinical investigations are warranted in determining the therapeutic and abuse liability of the salvinorin A chemical scaffold in animal models of psychiatric disorders and addiction liability before scheduling is implemented.

John

Vortherms, T.A., Roth, B.L.
Salvinorin A from natural product to human therapeutics
(2006) Molecular Interventions, 6 (5), pp. 257-265.
PermalinkPermalink 02/13/10 @ 12:47

In response to: Drug Addiction as a "Disease"

Harriett - nightlife cagayan de oro [Visitor] · http://spookscdo.com/
It's a disease, I totally agree.. Many factors are involve in it and practically those are the reasons why it can't be stop that simple.
PermalinkPermalink 02/12/10 @ 05:57

In response to: Proposed Regulation of Salvia Divinorum

john panos [Member]
Hello Professor,

Below are three references that would support that Salvinorin A and its analogs would be more appropriately listed as Schedule II rather than Schedule I compounds.

John

Bruijnzeel, A.W.
kappa-Opioid receptor signaling and brain reward function
(2009) Brain Research Reviews, 62 (1), pp. 127-146.

Carlezon Jr., W.A., Béguin, C., Knoll, A.T., Cohen, B.M.
Kappa-opioid ligands in the study and treatment of mood disorders
(2009) Pharmacology and Therapeutics, 123 (3), pp. 334-343.

Braida, D., Capurro, V., Zani, A., Rubino, T., Viganò, D., Parolaro, D., Sala, M.
Potential anxiolytic- And antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents
(2009) British Journal of Pharmacology, 157 (5), pp. 844-853.
PermalinkPermalink 02/08/10 @ 11:43

In response to: Proposed Regulation of Salvia Divinorum

john panos [Member]
DEA Drugs and Chemicals of Concern site.

http://www.deadiversion.usdoj.gov/drugs_concern/salvia_d/salvia_d.htm
PermalinkPermalink 12/01/09 @ 20:20
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