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Physical Dependence & Withdrawal Tests


The ability of addictive drugs to produce physical dependence is also studied at the ARU. The discomfort experienced during withdrawal of some drugs (e.g., heroin) has long been presumed a factor in continued drug intake and addiction. Physical dependence studies investigate the motivational properties of somatic withdrawal reactions. Although physical dependence is not a necessary condition for drug addiction, it may contribute to the total reinforcing impact of some drugs. Therefore, limited studies investigating physical dependence are conducted at the ARU.


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